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AcelRx Announces Positive Phase 2 Results From A Study Of ARX-01 Sufentanil NanoTabs In Treating Post-Operative Pain
AcelRx Pharmaceuticals, Inc. announced positive results from the second Phase 2 clinical study evaluating the safety and efficacy of its ARX-01 Sufentanil NanoTabs(TM) for the management of acute post-operative pain in patients requiring opioid analgesia during hospitalization. Compared to placebo, patients receiving ARX-01 Sufentanil NanoTabs for management of post-operative pain following major abdominal surgery reported statistically significant reductions in pain intensity over the 12-hour study period.
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Dozens Arrested In National Medicare Fraud Bust
The Associated Press reports: "Federal authorities arrested more than 30 suspects, including doctors, and were seeking others in a major Medicare fraud bust Wednesday in New York, Louisiana, Boston and Houston, targeting scams such as "arthritis kits" - expensive braces that many patients never used. More than 200 agents worked on the $16 million bust that included 12 search warrants at health care businesses and homes across the Houston area, where the bulk of the arrests were made. Federal authorities say those businesses were giving patients "arthritis kits," which were nothing more than expensive orthotics that included knee and shoulder braces and heating pads. Patients told authorities they were unnecessary and many never even received them. But health care clinic owners billed between $3,000 to $4,000 for each kit. ... In some cases, clinic owners billed patients who were dead when they allegedly received the items" (Kennedy, 7/29).
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Indiana University Simon Cancer Center's Tissue Bank Collecting Samples Aug. 8
Although Hispanic women tend to develop breast cancer less than Caucasian women, it is usually more aggressive and advanced when it does develop.
Sexual Health

A Cancer Gene Switch For Repairing Damaged DNA

Scientists at the Medical Research Council Laboratory of Molecular Biology uncover how an important cancer gene, BRCA1, works by increasing the accuracy with which broken DNA is repaired. Women who inherit a faulty version of the BRCA1 gene are at a higher risk of developing breast or ovarian cancer. In a research paper appearing in Nature on 21 May, Dr Kevin Hiom and Dr Maximina H. Yun from the Cambridge laboratory describe how an important cancer gene, BRCA1, works by increasing the accuracy with which broken DNA is repaired and thus reducing the risk of cancers developing. Mutations in the BRCA1 gene are associated with a significant increase in breast cancer risk and with the onset of ovarian cancer. By studying the interaction between BRCA1 and a protein called CtIP, the scientists discovered a switch that causes DNA breaks to be repaired using another identical piece of DNA as a template. Using the template makes sure the correct genetic sequence is restored without mistakes, thereby reducing the chance of introducing harmful mutations. Lead author Dr Hiom said: "Our findings help us to understand of how breaks in DNA strands can be repaired in a way that preserves our genetic code so that harmful mutations, which may lead to cancer, are kept to a minimum. We use chicken cells because they repair their DNA in a similar way to humans. Also we can easily create cells lacking different factors involved in DNA repair to study in the laboratory what happens when these factors are missing." "Up to now, it was unclear how this accurate mechanism for repairing DNA breaks is turned on so we are very pleased with the result." Cancer is caused by alterations in the sequence of the genetic material DNA. These mutations often arise when DNA becomes damaged, for example, through the generation of DNA breaks. Sometimes this damage is repaired accurately to restore the original DNA sequence and other times it is repaired inaccurately to produce a mutation. Together BRCA1 and CtIP act on broken ends to enable the reconstitution of one strand of a DNA helix to generate a region of single-stranded DNA. The generation of this single stranded DNA tail, which becomes the template for repair, is a critical step in the initiation of accurate DNA repair. By promoting the interaction of BRCA1 with CtIP it might be possible to increase the levels of accurate DNA repair and reduce the frequency of cancer causing mutations. Medical Research Council


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