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New Drug Combination Offers Novel Treatment Strategy For Non-Hodgkin's Lymphoma
Patients diagnosed with non-Hodgkin"s lymphoma who become resistant to standard therapies may have a new treatment option. Scientists in the Lymphoma Translational Research Laboratory at Roswell Park Cancer Institute analyzed the mechanisms to overcome treatment resistance, including a new drug combination. Francisco J. Hernandez-Ilizaliturri, MD , Departments of Medicine and Immunology, Roswell Park Cancer Institute (RPCI), will present the findings at the American Society of Clinical Oncology (ASCO) 2009 annual meeting, May 29 - June 2, in Orlando, FL.
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Parasites Ready To Jump
Transposons are mobile genetic elements found in the hereditary material of humans and other organisms. They can replicate and the new copies can insert at novel sites in the genome. Because this threatens the whole organism, molecular mechanisms have evolved which can repress transposon activity. Professor Klaus Förstemann of the Gene Center of Ludwig-Maximilians-Universität (LMU) in Munich and a team of researchers working with the fruitfly Drosophila melanogaster have now uncovered a new type of cellular defence that acts against DNA sequences present in high copy numbers inside the cell, even if they have not integrated into the genome. Small molecules of RNA (a class of nucleic acid closely related to the genetic material DNA) play the central role. "Transposons are genomic parasites, so to speak", says Förstemann. "If they are allowed to proliferate, the genome can become unstable or cancers can develop. We now want to find out whether mammalian cells possess this newly discovered defence mechanism and to elucidate precisely how it works." (EMBO Journal online, 30 July 2009.)
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Cell Communication Following DNA Damage Has Implications In Aging And Cancer
When cells experiencing DNA damage fail to repair themselves, they send a signal to their neighbors letting them know they"re in trouble. The discovery, which shows that a process dubbed the DDR (DNA Damage Response) also controls communication from cell to cell, has implications for both cancer and aging. The findings appear in the July 13 online edition of the Nature Cell Biology.
Diagnostics

AARP Responds To Health Reform Scare Tactics

AARP Executive Vice President John Rother issued the following statement in response to recent commentary by Betsy McCaughey in various media outlets on health care reform measures passed or currently being considered by Congress. "Betsy McCaughey"s recent commentary on health care reform column in various media outlets is rife with gross-and even cruel-distortions. "Ms. McCaughey has again launched her customary broadside attack against comparative effectiveness research. She describes this term as "code" for "limiting care based on a patient"s age." In fact the term for that is "age rating," a practice used by insurance companies to discriminate against older Americans against which AARP is vigorously fighting, and we look forward to her next column to help the cause. ""Comparative effectiveness research," on the other hand, is a technical term that just means giving doctors and patients the ability to compare different kinds of treatments to find out which one works best for which patient. "Some estimates say that only about half of all therapies that patients receive have been backed up by head-to-head comparisons with alternatives. While our country spends more than $2 trillion a year on health care, we spend less than 0.1 percent on evaluating how that care works compared to other options. "This research has been around (although sadly not enough) for decades, enjoying support from political leaders of both parties, doctors, patients, and consumer advocacy groups. "The main opponents of this research are those groups with a vested interest in a health care system that wastes billions of dollars each year on ineffective or unnecessary drugs, treatments or tests. Given Ms. McCaughey"s position as a Director of a medical device producer, I would hope that any potential conflict of interest has not influenced her commentary. "More concerning, Ms. McCaughey"s criticism misinterprets legislation that would actually help empower individuals and doctors to make their own choices on end-of-life care. "This measure would allow Medicare to pay doctors for taking the time to talk with individuals about difficult end-of-life care decisions. It would help provide people with better information on the positives and negatives-both physical and financial-that different treatments can mean for them and their families. "Facing a terminal disease or debilitating accident, some people will choose to take every possible life-saving measure in the hopes that treatment or even a cure will allow them more time with their families. Others will decide that additional treatment would impose too great a burden-emotional, physical and otherwise-on themselves and their families, declining extraordinary measures and instead choosing care to manage their discomfort. Either way, it should be their choice. "This measure would not only help people make the best decisions for themselves, but also better ensure that their wishes are followed. "To suggest otherwise is a gross, and even cruel, distortion-especially for any family that has been forced to make the difficult decisions on care for loved ones approaching the end of their lives. "AARP is committed to improving the quality, effectiveness, and affordability of health care for our 40 million members and their families. We will fight any measure that would prevent individuals and their doctors from making their own health care decisions. We will also fight the campaign of misinformation that vested interests are using to try to scare older Americans in order to protect the status quo. Profits should never be allowed to come before people in this debate." AARP


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