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Patients With Lower Urinary Tract Symptoms More Likely To Suffer From Metabolic Syndrome
Researchers have determined that individuals with mild to severe symptoms of lower urinary tract symptoms (LUTS) are more likely to suffer from metabolic syndrome (MetS), a collection of cardiovascular risk factors thought to be linked by insulin resistance). LUTS encompass voiding (incomplete emptying, weak stream, intermittency, straining) and storage (frequency, urgency, nocturia) difficulties.
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Gene Predicts How Brain Responds To Fatigue, Human Study Shows
New imaging research in the June 24 issue of The Journal of Neuroscience helps explain why sleep deprivation affects some people more than others. After staying awake all night, those who are genetically vulnerable to sleep loss showed reduced brain activity, while those who are genetically resilient showed expanded brain activity, the study found. The findings help explain individual differences in the ability to compensate for lack of sleep.
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Waits To See Specialists In Boston Increased To Average Of 50 Days, Study Finds
The average time patients in Boston wait for an appointment to see a specialist has increased over the last five years to an average of 50 days and can be up to one year, despite the fact that the city has an "abundance" of specialists, according to a recent study, the Boston Globe reports. For the study, Merritt, Hawkins & Associates, a Texas-based consulting and physician recruiting firm, surveyed 1,162 physician offices in 15 metropolitan areas to try to re-create the situation of a new patient seeking a nonurgent appointment in five specialty areas -- cardiology, dermatology, family medicine, obstetrics-gynecology and orthopedic surgery. The average wait time in Boston is more than three weeks longer than any other city included in the study. The study determined that while Boston patients had the longest wait times for appointments to see dermatologists, ob-gyns and family practitioners, Dallas had the longest wait times to see orthopedic surgeons, followed by Boston. Miami, Minneapolis and San Diego all had longer wait times to see cardiologists than Boston.According to the study, while Boston patients have long faced delays, the problem may have been exacerbated by an increase in patients seeking care following the implementation of the 2006 Massachusetts health insurance law. While the study did not pinpoint a cause for longer wait times in Boston, the study"s authors wrote that the city"s experience "may signal what could happen nationally in the event that access to health care is expanded through health care reform."Brian Rossman, research director for Health Care for All, said the reason for long wait times also is because many specialists in Boston work for academic medical centers and do not see patients full time (Kowalczyk, Boston Globe, 5/15).
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Call To Tackle The Causes Of Ageing Rather Than Treating The Effects

Tackling the very causes of ageing, rather than treating the symptoms in a piecemeal way offers the best prospects for dealing with the diseases and effects of ageing according to a public lecture being given at the Royal Society tonight. New research that offers up hope to improve health during ageing in humans, and to tackle a broad range of ageing-related diseases, will be presented tonight by Director of the UCL Institute of Healthy Ageing Professor Linda Partridge. She believes these scientific advances are inspiring a new wave in ageing research. Professor Partridge says: "Research on the diseases associated with ageing is generally done by separate communities of research workers who read different journals, attend different conferences and generally do not communicate with each other. But by tacking the causes of ageing itself we could treat, or at least delay, a broad spectrum of conditions simultaneously" Two discoveries are proving especially exciting in the field. Mutations in single genes have been found to extend the lifespan of animals in the lab - such as worms, fruit flies and mice - and appear to play the same role in humans. And these mutations can also produce a broad-spectrum improvement in health during ageing. So far, signalling pathways that sense nutrients have proved to have the most robust effect on healthy lifespan. For instance, in mammals insulin regulates blood sugar levels and metabolism in response to food intake, while the related insulin-like growth factor 1(Igf1) regulates growth. Mutations in genes that encode the protein components of the insulin and Igf1 signalling pathways have proved to extend lifespan in a nematode worm, the fruit fly and mice, and genetic variants for these genes in humans have proved to associate with lifespan. Dietary restriction, which is a simple environmental intervention, can also extend life in a range of animals. Drugs which inhibit the nutrient pathways in humans could replicate the effects of dietary restriction and act not only to increase healthy lifespan but to target a broad range of ageing related diseases such as cardiovascular disease, cancers, diabetes and Alzheimer"s. This research means a new approach to the treatment of age-related conditions. Partridge adds: "The major burden of ill health is in the older section of the population. The new discoveries about ageing have raised the prospect of increasing the number of years that people enjoy in good health, with broad-spectrum preventative medicines for the diseases of ageing" Professor Partridge will be speaking as the latest winner of The Croonian Prize. The Croonian Lecture is the Royal Society"s premier lecture in the biological sciences. The Royal Society


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