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Autism-Mitochondrial Study: Participants Needed
ASD Centers, LLC has expanded the clinical study started in the Dallas, Texas area to include other locations. This study is designed to examine mitochondrial dysfunction and how L-carnitine supplementation affects behavior, cognition, muscle strength, and health/physical traits in those with a diagnosed autism spectrum disorder (ASD).
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Healthier, Longer-Lasting Fish Filets With Edible Coating
Consumers may be able to eat longer-lasting, potentially healthier fish fillets if research at Oregon State University makes its way to the supermarket.
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Parasites Ready To Jump
Transposons are mobile genetic elements found in the hereditary material of humans and other organisms. They can replicate and the new copies can insert at novel sites in the genome. Because this threatens the whole organism, molecular mechanisms have evolved which can repress transposon activity. Professor Klaus Förstemann of the Gene Center of Ludwig-Maximilians-Universität (LMU) in Munich and a team of researchers working with the fruitfly Drosophila melanogaster have now uncovered a new type of cellular defence that acts against DNA sequences present in high copy numbers inside the cell, even if they have not integrated into the genome. Small molecules of RNA (a class of nucleic acid closely related to the genetic material DNA) play the central role. "Transposons are genomic parasites, so to speak", says Förstemann. "If they are allowed to proliferate, the genome can become unstable or cancers can develop. We now want to find out whether mammalian cells possess this newly discovered defence mechanism and to elucidate precisely how it works." (EMBO Journal online, 30 July 2009.)
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Chronic Pelvic Pain Syndromes: Clinical, Urodynamic, And Urothelial Observations

UroToday.com - Patients with pain can present with various symptom complexes that include interstitial cystitis, vulvodynia, irritable bowel syndrome, myofascial pain or various causes of dyspareunia but when carefully evaluated, the majority have very similar findings. No matter what their primary complaint might be over 70% of patients will have hypertonic pelvic floor dysfunction and/or pain as well as a component of at least one visceral pain syndrome such as interstitial cystitis (the most common), chronic pelvic pain or irritable bowel syndrome. Given what we know about visceral pain syndromes it should not surprise us that the majority of patients with chronic pain have multiple pain generators and we must aggressively look for each of these pain generators. It is only through the identification and treatment of each of these pain generators that we can expect to down regulate the dorsal horn and help these patients and their allodynic manifestations of their pain disorders. This study points out that therapeutic anesthetic cocktails are very helpful in the majority of patients no matter what their chief complaint would be thus the urothelium must be evaluated as a possible pain generator in the majority of our patients with pelvic pain. Finally, the clinician must be aware that five to ten percent of patients that present with urinary incontinence or pelvic organ prolapse may also have a chronic pain disorder that must be identified and treated prior to any surgical intervention. Many of our patients learn to accept chronic pain, pain with intercourse, or urinary frequency because they have had these problems for many years so that when they present with a problem such as stress incontinence or prolapse their pain disorder will often be overlooked unless this unfortunate patient has a postoperative exacerbation of her pain problems. Written by Charles W. Butrick, MD as part of Beyond the Abstract on UroToday.com UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice. To access the latest urology news releases from UroToday, go to: www.urotoday.com Copyright © 2009 - UroToday


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