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A Cancer Gene Switch For Repairing Damaged DNA
Scientists at the Medical Research Council Laboratory of Molecular Biology uncover how an important cancer gene, BRCA1, works by increasing the accuracy with which broken DNA is repaired. Women who inherit a faulty version of the BRCA1 gene are at a higher risk of developing breast or ovarian cancer.
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New Clinical Research Organization Established In West Palm Beach, Florida
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Every Daytime Sedentary Hour Adds Three Minutes To Time Children Take To Fall Asleep

Every hour of the day children are inactive adds three minutes to the time it takes them to fall asleep, finds research published ahead of print in Archives of Disease in Childhood. Children who fall asleep faster also sleep for longer, the study shows, even though one is not the direct consequence of the other. Research indicates that around 16% of parents of school aged children say that their child finds it difficult to get to sleep. Poor sleep patterns in children have been associated with poorer school performance and an increased risk of overweight and obesity. The authors studied the daytime activity and sleep patterns of a representative sample of 591 seven year olds, using an activity monitor (actigraph) worn for 24 hours. Full information on sleep patterns was available for 519 of the children, who took an average of 26 minutes to fall asleep, known as sleep latency, but ranging from 13 to 42 minutes (interquartile range). Around one in 10 of the children regularly found it difficult to fall asleep quickly, their parents reported, and these children took around 15.5 minutes longer to get to sleep. Children who were physically active during the day, fell asleep more quickly than their more sedentary peers, and the more vigorous activity they did, the faster they fell asleep. On the other hand, every hour of the day spent in sedentary activity increased sleep latency by 3 minutes. Shorter sleep latency was also linked to longer duration of sleep. It fell by more than 11 minutes for each additional hour of sleep. These results will confirm what many parents already believe - that tiring out a child with plenty of physical activity will increase the chances that s/he will sleep well, say the authors. "This study emphasises the importance of physical activity for children, not only for fitness, cardiovascular health and weight control, but also for sleep," they conclude. "Falling asleep: the determinants of sleep latency" Online First Arch Dis Child 2009; doi 10.1136/adc.2009.1574453 Archives of Disease in Childhood


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