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AFFiRiS AG: Atherosclerosis Vaccine Development Receives EU Support
The atherosclerosis vaccine development program by AFFiRiS AG is receiving financial support from the EU"s EUROTRANS-BIO call. The respective project is being carried out in cooperation with German company EMC microcollections GmbH. The aim of atherosclerosis vaccination is to increase the amount of "good" high density lipoprotein cholesterol (HDLc) in the blood and thus reduce the occurrence of harmful fatty deposits in the arteries. Product candidates were delivered by AFFiRiS" AFFITOME(R) platform technology. The target is a protein known as CETP (cholesteryl ester transfer protein). Following vaccines for Alzheimer"s disease and Parkinson"s disease, the atherosclerosis vaccine is the third such project announced by AFFiRiS AG.
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Two Studies Report Finding New Genes And Gene Regions That Make People Susceptible To MS
Two studies recently published in the journal Nature Genetics report identifying new genes and gene regions that contribute to making people susceptible to developing MS. The findings, by the International Multiple Sclerosis Genetics Consortium and the Australia/New Zealand MS Genetics Consortium, add to a growing list of gene variations linked to MS susceptibility. Identifying all MS genes will likely lead to the development of more effective ways to treat the disease, and open the door to uncovering the cause of MS, which may lead to its prevention.
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A National Autistic Society (NAS) Response To The National Audit Office (NAO) Report On Adults With Autism
Mark Lever, NAS chief executive said; "In the current economic climate the Government cannot possibly ignore the huge cost savings and benefits, identified by their own auditing body, of providing adults with autism with the right support at the right time. Neither the Government, people with autism nor the taxpayer are getting value for money from existing autism services and support, leaving those affected by the condition feeling isolated, ignored and often at breaking point. This is simply unacceptable.
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Improved Communication Encourages Patients To Seek Colorectal Cancer Screening, Study Finds

Improved communication among patients and primary care physicians increases the chances those due for colorectal cancer screening will follow their doctors" advice and complete the procedure, a University at Buffalo study has found. The research by principal investigator Thomas Feeley, Ph.D., UB associate professor and a specialist in health communication, also found the more convenient the screening process was, the greater the chance patients would follow through and be tested for colon cancer. Feeley holds faculty appointments in communication, family medicine and nursing at UB. The study appears in the June issue of Health Communication. "It became apparent during the study," says Feeley, "that the communication related to cancer screening between health care provider and patient was positively related to an individual going through with the screening recommendation of the physician." Feeley"s research, based on 27 one-hour focus groups with patients, physicians, nurse practitioners and physicians" assistants, found lack of time, patient reluctance and difficulty in scheduling the test itself as reasons people ignored or failed to follow the recommendations made by their primary care physician. Physician recommendation and knowing someone who has or had cancer were the most common factors motivating patients" decisions to complete colorectal cancer screening, the study concludes. James Cooper and Martin C. Mahoney, both of Roswell Park Cancer Institute, and Thomas Foels of Independent Health Association were co-investigators on the study. The study identified a host of reasons why patients whose doctors had recommended they undergo this test avoided doing so. The reasons included fear of the test, embarrassment, fear of the results, the cost of the test and lack of time. The study found several effective measures physicians can take to help their patients overcome the barriers and take the screening test: The more persistent doctors were in discussing colon cancer screening with patients, the more likely the patients would take the test. When the office personnel of primary care doctors scheduled the test for their patients, the "attrition levels" between the time the physician recommended the test and when these patients actually underwent the test decreased, according to patients" testimony. In other words, the more involved the doctor"s office was in the tests, the greater the chances patients would actually go through with the test. The vicarious experience of patients facing the screening test also influenced whether the patient would follow through with the test. "On the negative side, many patients parroted reports from colleagues and friends about the horrors of the prep and embarrassment related to the colorectal screening," Feeley explains. "At the same time, many parents cited children and spouses as their inspiration to get screened; loved ones often tempered the negative response about screening presented in the break room or in the hallways at work." The words of physicians also had an impact on patients" willingness to take the screening test. "One physician reported the use of analogies," Feeley says. "For example, the physician said, "It is like taking care of your car; you must change the oil and check the engine to make sure all is going well."" But the study stressed this kind of physician-patient communication that often persuades the patient to take the screening test is hampered when the visits are rushed and distracted. "Any proper attempt to allay patient fears associated with colorectal cancer screening or efforts to communicate the value of preventive medicine requires ample time for effective dialogue," Feeley says. Colorectal cancer is the second most common cause of cancer-related deaths in the United States, and the third most commonly diagnosed cancer among men and women, the researchers point out. The American Cancer Society estimates that 112,340 new cases of colorectal cancer will be identified this year, and more than 52,000 people would die from colon and rectal cancer. Most cases are detected at an advanced stage, when the chances the patient can recover decrease. The National Cancer Institute estimates that the five-year survival rate for colorectal cancer is about 70 percent. Screening patients with no symptoms of colorectal cancer for precancerous lesions greatly reduces the chances patients with these cancers will die from the disease. Although the test is quick, largely painless and not expensive, some studies estimate fewer than 45 percent of the patients who should sign up for the test actually go through with the procedure. Charles Anzalone University at Buffalo


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