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New Market Research Study Shows Lung Cancer Treatments Differ Significantly By Both Age And Geography
There are striking differences in treatment regimens for non-small cell lung cancer (NSCLC) patients, based on both age and geography, according to a new market research study conducted by Merck KGaA, Darmstadt, Germany, presented as a poster on Saturday at the 2009 ASCO (American Society of Clinical Oncology) meeting in Orlando, Florida (Abstract no.: 8053; Poster no.: N15). Performed in conjunction with TNS Healthcare, the representative study shows that among patients with advanced NSCLC, monotherapy is used most often among those 70 or older, while combination therapies are administered most frequently to younger patients. Location also is a key factor in determining therapy choice, with a chemotherapy doublet plus a targeted agent far more common in the US than in Europe.
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Supreme Court Nominee Sotomayor Resumes Meetings With Senators; Confirmation Vote Still Unclear
Judge Sonia Sotomayor, President Obama"s nominee for the Supreme Court, on Thursday will hold a third round of private meetings with senators who will be voting on her confirmation, the AP/Chicago Tribune reports. The AP/Tribune reports that by Friday, Sotomayor will have met with more than one-quarter of the Senate and a majority of members on the Senate Judiciary Committee, which will lead an as-yet-unscheduled set of hearings for her confirmation.The Judiciary Committee is expected to receive and examine a large collection of documents for the hearings -- including Sotomayor"s writings, speeches and unpublished rulings -- as part of a questionnaire response on personal and financial data, possible conflicts of interest and the procedure that led to her nomination. According to the AP/Tribune, the White House in recent days has been rallying support for Sotomayor, with first lady Michelle Obama on Wednesday talking about the nominee at a high school graduation (Hirschfeld Davis, AP/Chicago Tribune, 6/4).Meanwhile, Senate Judiciary Committee Chair Patrick Leahy (D-Vt.) and ranking member Jeff Sessions (R-Ala.) on Wednesday failed to reach an agreement on a timeline for Sotomayor"s confirmation hearings and vote, CongressDaily reports. According to CongressDaily, Democrats and Republicans generally are "at odds" over the issue, particularly over when the confirmation hearings should start (Friedman, CongressDaily, 6/3). Leahy said that he would like hearings to begin next month, with the goal of scheduling a confirmation vote before the month-long congressional recess that begins in early August. Sessions has called for the process to be spread out over the summer to allow committee members to analyze the large volume of Sotomayor"s records, with hearings beginning in September (AP/Chicago Tribune, 6/4).Leahy -- who will have the final say on the start of the hearings -- on Tuesday said that "it would be irresponsible to leave [Sotomayor] hanging out there" until September (CongressDaily, 6/3).
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In A Chemical Library, Yale Researchers Find Keys To Cell Movement
Rummaging through a biotechnology company"s chemical closet, Yale University researchers found two molecules that will allow scientists to better study how cells move. The study in the journal Nature, published online Aug. 2, describes how two small molecules discovered by Cytokinetics Inc. block the action of a key complex that directs the assembly of actin filaments, which produce the force to help cells move. The target of these inhibitors is the Arp2/3 complex, a cellular component so vital that cells die without it. This dependence has made it challenging to learn exactly which cellular processes depend upon the complex.
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Minor League Hockey Players Unable To Identify Concussion Symptoms, Study Says

When Chicago Blackhawk"s leading scorer Martin Havlat returned to the ice for game four of the Western Conference Final after sustaining a concussion only two days earlier, questions were raised surrounding his swift return. According to a new study by St. Michael"s Hospital neurosurgeon Dr. Michael Cusimano, similar questions were raised by 25% of minor league hockey players who did not know if an athlete with symptoms of a concussion should continue to play hockey. Nearly a majority of these players were also unable to identify a concussion or its related symptoms. The findings are part of a study by Dr. Cusimano that analyzed the concussion knowledge of 142 adults (coaches, trainers and parents) and 267 players from GTA Atom (10-years-old), Bantam (14-years-old), AA (highly competitive) and house league divisions. The study is published in the May edition of the Canadian Journal of Neurological Sciences. "Serious misconceptions exist among minor league hockey players, athletes, coaches and parents when it comes to understanding the signs and symptoms of a concussion and its treatment," said Dr. Cusimano, a professor of neurosurgery, education and public health at the University of Toronto and vice-president of ThinkFirst Canada, a national injury prevention organization. "While many can identify how a concussion may occur, most cannot identify the symptoms and are under the impression that concussions can be treated with physician-prescribed medication or physical therapy. Many also believe it"s okay to return to play before they have fully recovered from such a brain injury. This is troublesome since repeated brain injuries can lead to long term effects in functions such as memory, behaviour, mood, social relations and school or work performance." Key findings of the study include: * Up to two thirds of players had the mistaken impression that a player does not have to lose consciousness to have suffered a concussion * A quarter of adults and up to half of children could not identify any symptoms of a concussion or could name only one symptom of a concussion. * About one-half of players and a fifth of adults mistakenly believed concussions are treated with medication or physical therapy * About a quarter of all players did not know if an athlete experiencing symptoms of a concussion should continue playing * About 4 in 10 of younger players and 3 in 10 of the older players thought a concussed athlete could return to play when feeling "90% better" or "while experiencing a mild headache for the next game as long as it"s at least two days later." In Canada, ice hockey is the main cause of sports-related traumatic brain injury. Statistics suggest youth 5-17 have about 2.8 concussions per 1,000 player-hours of ice hockey while university and elite amateur players sustain rates of 4.2 and 6.6 concussions per 1,000 player hours. Concussions have forced many NHL players like Brett Lindros and Pat LaFontaine to retire early and others like Eric Lindros and goalie Mike Richter to stay off the ice for an extended time because of repeated head injuries. Concussions can have cumulative and lasting effects on memory, judgment, social conduct, reflexes, speech, balance and co-ordination. Key to preventing repeated injuries is to recognize the symptoms of concussion when they occur and knowing how to deal with their effects. "Motivation to win, the wish to advance in their sport and earning the acceptance of their team-mates often outweigh an athletes" decision, or their parents" or coaches" decision, to play safe. This mind-set, coupled with the influence of media and behaviour of some parents, coaches and officials, unfortunately send a clear message that it is more important to continue to play injured than take someone out of the game," said Dr. Cusimano. "This "win at all costs" attitude places added responsibility on parents, coaches and medical professionals to recognize symptoms of a concussion and take all necessary steps to ensure a culture of healthy attitudes and behaviours among players and in leagues." Changes in rules such as removing fighting and body checking, proper use of helmets, softer shoulder and elbow pads, improved enforcement of rules, educational efforts and recognizing the critical role that professionals and the media have in shaping the culture of the sport would be beneficial, he added. Julie Saccone St. Michael"s Hospital


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