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As The Market Potential Grows, Developers Press For Keys To Delivering Systemic Drugs Via Inhalation
At a time when the drug industry is striving for patient-friendly delivery methods for new and existing drugs, the growing availability of innovative inhaler device designs is driving interest in pulmonary drug delivery technology and devices as an alternative to oral and parenteral routes of administration. While well-established for treating upper respiratory diseases such as asthma and COPD, companies competing in the inhaled drug delivery sector - major players such as GlaxoSmithKline, AstraZeneca and Boehringer Ingelheim as well as pure-play start-ups - continue to view delivery of systemic drugs via inhalation as a major opportunity.
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Need Something? Talk To My Right Ear!
We humans prefer to be addressed in our right ear and are more likely to perform a task when we receive the request in our right ear rather than our left. In a series of three studies, looking at ear preference in communication between humans, Dr. Luca Tommasi and Daniele Marzoli from the University "Gabriele d"Annunzio" in Chieti, Italy, show that a natural side bias, depending on hemispheric asymmetry in the brain, manifests itself in everyday human behavior. Their findings were just published online in Springer"s journal Naturwissenschaften.
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Gene Predicts How Brain Responds To Fatigue, Human Study Shows
New imaging research in the June 24 issue of The Journal of Neuroscience helps explain why sleep deprivation affects some people more than others. After staying awake all night, those who are genetically vulnerable to sleep loss showed reduced brain activity, while those who are genetically resilient showed expanded brain activity, the study found. The findings help explain individual differences in the ability to compensate for lack of sleep.
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National Public Reporting Of Health-Care-asociated Infections Supported By Experts

Five organizations representing the nation"s experts in infectious diseases medicine, infection prevention in healthcare settings, and public health and disease prevention announced their support for a provision requiring national reporting of healthcare-associated infection (HAI) rates, which is contained within the healthcare reform bill introduced by leaders of the U.S. House of Representatives. The Association for Professionals in Infection Control and Epidemiology (APIC), the Society for Healthcare Epidemiology of America (SHEA), the Infectious Diseases Society of America (IDSA), the Council of State and Territorial Epidemiologists (CSTE) and the Trust for America"s Health (TFAH) sent a joint letter to members of Congress who will be voting on the legislation (HR 3200, the America"s Affordable Health Choices Act) in the coming days. The bill would require hospitals and ambulatory surgical centers to report HAI data through an existing national reporting network managed by the Centers for Disease Control and Prevention (CDC) as a condition of participation in Medicare and Medicaid. "Overall -- this is a win for patients," said APIC 2009 President Christine J. Nutty, RN, MSN, CIC. "Public reporting of HAIs may drive further improvement in healthcare processes which will reduce infections, save lives, and preserve healthcare dollars. We are pleased that the House bill would also address the need for highly trained staff to effectively implement the system." In the U.S., HAIs claim 99,000 lives annually and incur more than $20 billion in excess healthcare costs. "This legislation will assure accountability and transparency as the nation moves to address this growing public health problem," said Jeffrey Levi, PhD, Executive Director of Trust for America"s Health. "Patients have a right to know how well they are protected from healthcare-associated infections and this level of openness will encourage healthcare facilities to improve their outcomes." The groups agreed that the public reporting provision found in HR 3200 is superior to approaches that have been put forth in other legislation. HR 3200 will establish a single national standard for HAI reporting, and it will ensure that public health scientists at CDC determine which infections are reported and how. By mandating reporting via CDC"s National Healthcare Safety Network, the bill will build on existing mechanisms and create the robust system we need to monitor, study, and ultimately prevent HAIs. "Using CDC"s network means that everyone will be looking for the same information in the same way," said Mark E. Rupp, MD, president of SHEA. "This approach for HAI reporting will be a more accurate way to compare local and national infection rates and trends. This will give us the science base we need to better prevent HAIs." One element missing from the bill, the organizations noted, was the lack of a much-needed, strengthened federal approach to deal with antimicrobial resistant organisms. "Overall, we applaud the approach taken on public reporting," said Anne Gershon, MD, FIDSA, president of IDSA. "However, we hope congressional leaders also will adopt new strategies to address drug-resistant pathogens, which are the cause of so many debilitating infections and patient deaths in healthcare facilities each year." To address antimicrobial resistant organisms, the groups have urged Congress to amend HR 3200 to include the Strategies to Address Antimicrobial Resistance (STAAR) Act, H.R. 2400, introduced earlier this year by Rep. Jim Matheson (R-UT), which will build up federal efforts on surveillance, research, and prevention and control of drug-resistant infections. Liz Garman Infectious Diseases Society of America


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