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PTC Therapeutics Initiates Phase 2 Clinical Trial Of PTC299 In Patients With Neurofibromatosis Type 2
PTC Therapeutics, Inc. (PTC) announced the initiation of a Phase 2 clinical trial of PTC299 in adult patients with neurofibromatosis type 2 (NF2), a rare genetic disorder that causes the development of non-malignant brain tumors. PTC299 is a novel, orally administered investigational new drug that is designed to selectively block tumor-related vascular endothelial growth factor (VEGF). With its novel mechanism of action, PTC299 has the potential to meet significant unmet medical need in NF2 and other conditions resulting from the overexpression of VEGF.
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California Govenor Outlines Cuts To Address State's Budget Deficit Problems
California Gov. Arnold Schwarzenegger (R) outlined two budget proposals to address the state"s budget problems, and both plans would affect health care, the Los Angeles Times reports. The first proposal addresses the situation if California voters approve a set of special ballot measures intended to provide funds for fiscal year 2009-2010. The state would still face a $15.4 billion budget deficit even if voters approve the measures, and the second proposal addresses that scenario (Rothfeld, Los Angeles Times, 5/15). The governor proposed $750 million in cuts to Medi-Cal, the state"s Medicaid program, that would reduce eligibility and provider rates. The state would need to seek a federal waiver to implement the cuts. The governor also proposed eliminating eligibility for non-emergency Medi-Cal benefits for documented immigrants (Colliver, San Francisco Chronicle, 5/15). Spending for centers that provide services to people with developmental disabilities would be cut by $234 million (Zapler, San Jose Mercury News, 5/14).If voters do not approve three ballot measures, Schwarzenegger outlined $800 million in additional cuts to health and human services programs, including a proposal to eliminate Healthy Families coverage for about 225,000 children. Healthy Families is California"s CHIP (Yi et al., San Francisco Chronicle, 5/15).
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Understanding Of Antidepressant Drugs Enhanced By New Mouse Model Of Depression/Anxiety
A recent study finds that the antidepressant effects of drugs like Prozac involve both neurogenesis-dependent and -independent mechanisms, a finding that may lead to development of better treatments for depression and anxiety. The research, published by Cell Press in the May 28th issue of the journal Neuron, utilizes a new experimental mouse model of depression/anxiety that is the first to permit simultaneous examination of multiple effects of antidepressant treatment in the same animal.
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New American Medical Association AD Emphasizes Common Ground On Health Reform, Shares Vision To Fix Broken System

Underscoring the need for meaningful health system reform for America"s patients and physicians, the American Medical Association (AMA) is running an ad emphasizing common ground on health reform to remember what"s at stake - access to care for millions. The AMA ad runs nationally today in the Chicago Tribune, New York Times, and the Wall Street Journal. Online advertising will run in various medical trade publications. "This ad is a reminder of why the AMA is working for reform," said AMA President J. James Rohack, M.D. "Forty-seven million Americans don"t have health insurance, and physicians work day and night to provide patients with high-quality care within the confines of a broken system." "Recognizing that there is still much to be done to achieve the right health reforms, the AMA is using this opportunity to get the facts out and find common ground," said Dr. Rohack. "It"s time to shift our focus from arguing about differences to working together to resolve them. The AMA is committed to reform to make the system better for patients and physicians." The AMA ad lists the organization"s health-reform goals: - Protect the sacred relationship between patients and their physicians, without interference by insurance companies or the government - Provide affordable health insurance for all through a choice of plans and eliminates denials for pre-existing conditions - Promote quality, prevention and wellness initiatives - Repeal the Medicare physician payment system that harms seniors" access to care - Ease the crushing weight of medical liability and insurance company bureaucracy "Our system is at a point where the status quo is no longer acceptable," said Dr. Rohack. "The AMA takes its position at the center of the health-care debate as both an honor and serious responsibility." The AMA invites all patients and physicians to become involved in the health-reform debate. For more information, please visit http://www.ama-assn.org/go/reform. American Medical Association


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