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InteKrin Therapeutics To Present At The 2009 American Diabetes Association Annual Meeting
InteKrin Therapeutics, Inc. announced it will present Phase 2a clinical data for INT131, a Selective PPAR Modulator (SPPARM), at the American Diabetes Association annual meeting in New Orleans Saturday, June 6, 2009 during the "Novel Diabetes Therapies in Development in Humans" session at 4:00 pm CDT.
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Budget Cuts For Minnesota Health Care Programs, Again
Minnesota Gov. Tim Pawlenty, R-Minn., announced Tuesday that "health and human services will come in for $236 million in additional cuts as part of his unallotment strategy," the Star Tribune reports. The "list of about 20 cuts to health services" includes ending a health care program for the poor "six weeks sooner than expected, saving $15 million" and "reducing hours for personal care attendants, who serve fragile and disabled people." Pawlenty "noted he was proposing no new payment reductions for primary care doctors and clinics, and no additional cuts in Medicaid reimbursements to hospitals that serve a large number of poor patients."
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Cystathionase Regulated By Farnesoid X Receptor
The expression and activity of Cystathionase is reduced in rodent models of liver injury, leading to hyper-homocysteinemia and impaired generation of hydrogen sulphide, two factors that contribute to endothelial dysfunction and increased intrahepatic resistance.
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Probiotics Can Increase Effectiveness Of Some Antibiotic Therapies For Bacterial Vaginosis

Antimicrobial treatments for bacterial vaginosis (BV) are effective, but taking lactobacillus tablets alongside metronidazole antibiotic therapy increases effectiveness over taking this antibiotic alone, according to a Cochrane Systematic Review. The researchers also concluded that intravaginal lactobacillus was as effective as oral metronidazole, although they did note unexplained drop-outs from the trials. BV is a very common vaginal infection. Traditionally, antibiotics in tablet or gel form have been given to treat the disease, but some have unpleasant side effects. BV is usually a mild disease and can pass unnoticed but is associated with an increased risk of HIV transmission. "Treating BV could help reduce susceptibility of women to HIV. Therefore it is important, particularly in the developing world, to establish the most effective and appropriate forms of treatment," says lead researcher Oyinlola Oduyebo, of the Department of Medical Microbiology and Parasitology at the University of Lagos in Lagos Nigeria. The researchers reviewed 24 trials involving 4,422 people. The antibiotics clindamycin and metronidazole both cured BV in over 90% of cases within two to three weeks, although there was a high rate of relapse. Side effects of metronidazole included nausea and a metallic taste in the mouth. However, it is the cheaper option and therefore likely to remain the most widely used in developing countries. Lactobacillus probiotic taken alongside metronidazole and taken intravaginally both showed significant effectiveness. Hydrogen peroxide and triple sulphonamide cream were not effective. "There are a range of good treatments for BV, but the high relapse rates require more attention and indicate that we need more research into other agents that can increase their effectiveness," said Oduyebo. "We also need to understand why so many people dropped out of the Lactobacillus trials as this suggests there are unreported adverse effects." Jennifer Beal Wiley-Blackwell


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