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Shocking New Figures Of Diabetes Complications Released, UK
New figures from the NHS Information Centre reveal a sobering tally of over 300 heart attacks, 300 strokes, 65 foot or toe amputations and 38 leg amputations among people with diabetes each week.
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Johns Hopkins Scientists Out A Gene For Gout
Having partnered last year with an international team that surveyed the genomes of 12,000 individuals to find a genetic cause for gout, Johns Hopkins scientists now have shown that the malfunctioning gene they helped uncover can lead to high concentrations of blood urate that forms crystals in joint tissue, causing inflammation and pain - the hallmark of this disease.
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A Cancer Gene Switch For Repairing Damaged DNA
Scientists at the Medical Research Council Laboratory of Molecular Biology uncover how an important cancer gene, BRCA1, works by increasing the accuracy with which broken DNA is repaired. Women who inherit a faulty version of the BRCA1 gene are at a higher risk of developing breast or ovarian cancer.
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SLU Explores Best Ways To Use Standard TB Vaccine

In a study funded by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, Saint Louis University"s Center for Vaccine Development is investigating whether the standard vaccine used in foreign countries against tuberculosis offers better protection as a shot, drink or combination of both. "The fight against tuberculosis is important because a third of the world is thought to be infected and there are significant problems with drug-resistant TB organisms," said Daniel Hoft, M.D., Ph.D., principal investigator and director of the division of immunobiology at Saint Louis University School of Medicine. The "standard" tuberculosis vaccine, bacillus Calmette-Guçİrin (BCG), is given to infants in foreign countries, and is not currently recommended for use in the U.S. "Experts believe it provides some protection against TB disease, particularly in children where severe manifestations of TB are averted," Hoft said. "However, despite widespread use of BCG, TB remains a major cause of death worldwide. The main purpose of this study is to find out if BCG can be used in a more effective way. "We hope to learn whether a BCG vaccine drink or a combination of a drink and an injection could increase immune responses against tuberculosis lung infection and affect the progression of the disease as it spreads throughout the body." The study also will look at whether it is better to give one or two doses of the BCG vaccine. A total of 70 healthy volunteers who are 18 to 40 years old are needed for the research. The study will last about two years and requires up to 21 scheduled visits. Each visit takes between 30 minutes and three hours, depending upon the procedures being performed. Study participants will be compensated for their time and travel after each completed visit. Tuberculosis is a deadly disease that strikes developing nations hardest. Each year, nearly 8 million new cases of TB develop, and 2 million persons die from the infectious disease. Saint Louis University Medical Center


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