Cardiovascular
Over 50 pharmacists have been trained to provide seasonal flu vaccinations under a private Patient Group Direction that the NPA is facilitating. Training days were conducted in London and Birmingham with further training days scheduled at the start of September 2009 in Newport, Durham, St Albans and Haydock.
Nearly three decades after China implemented its one-child policy, the city of Shanghai is planning to encourage young couples to have a second child in an effort to address the country"s aging population and shrinking work force, the New York Times reports. The city"s plan is the most public effort made by the government to counteract a program that is "considered both a tremendous success and a terrible failure," the Times reports. The policy has managed to keep population growth under control but also has led to forced abortions, according to the Times.The country is not abandoning the one-child policy, which applies mostly to residents in urban areas. Rather, the government is allowing more exceptions to the rule, with Shanghai -- where about 22% of its 20 million residents are older than age 60 -- leading the effort. China as a whole faces a similar problem seen in Shanghai, the Times reports. About 8% of the country"s population was older than age 65 in 2006. That figure is expected to increase threefold by 2050 to about 322 million people, or nearly 25% of the population, according to the United Nations.In Friday"s issue of China Daily, Xie Lingli, director of the Shanghai Population and Family Planning Commission, was quoted as saying, "We advocate eligible couples to have two kids because it can help reduce the proportion of the aging people and alleviate a work force shortage in the future." City officials plan to visit homes, pass out leaflets, and offer counseling and financial incentives, the Times reports. Current exceptions to the one-child policy are in place for ethnic minorities and rural residents, who can have a second child if the first child is a girl. Couples made up of two parents who have no siblings have always been allowed to have a second child and are now being encouraged to do so (Barboza, New York Times, 7/24).
"The current debate over government funding for abortion in the health care plan is a reminder of how we have failed poor women," Frances Kissling writes in a Salon opinion piece. According to Kissling, the 32-year-old Hyde Amendment, which prohibits federal funding for abortion services, has played a large role in denying impoverished women access to the procedure. "Restoring those funds has not been a top priority for pro-choice advocates, who sadly concluded that because the public does not care about poor women and is actually hostile to poor women who have sex and become pregnant, it would be futile to put too much capital into reversing Hyde," Kissling writes.However, "we have an opportunity to make amends" by reversing the Hyde Amendment and restoring federal funding for abortion services, according to Kissling. "But the portents are not promising," she writes, adding that a group of "pro-life" Democrats in the House in a recent letter to House Speaker Nancy Pelosi (D-Calif.) "laid down the first major antiabortion challenge to health care reform." In addition, the Obama administration "has refused to rule out including abortion in the health care package, but President Obama is already signaling that the status quo on abortion is likely to endure," Kissling writes."The longer it takes to pass a plan, the more momentum against including coverage for abortion -- and possibly contraception -- will build," Kissling writes, adding that "there is a good chance there will be limits on government funding for abortions in the health care package, if not outright exclusion." A compromise being considered by the House Energy and Commerce Committee would not prohibit or require private insurers offering government plans from covering abortions but would prohibit the use of federal funds to pay for them. "Whether this would result in a reduction of coverage in such plans is unclear, but it is possible," she continues."The timing is critical. The need is great, and growing," Kissling writes, adding, "If abortion services are excluded from the health care reform package, the number of women who will not be able to afford abortions is bound to rise and the number of unwanted children will increase." Kissling concludes, "One hears over and over again that we all agree that the health care system is broken; the status quo is not acceptable. The status quo on coverage for abortion is especially unacceptable" (Kissling, Salon, 7/27).
"A new fault line has opened in the abortion debate," and the "fight is no longer between pro-lifers and pro-choicers" but between "militants and pragmatists," Slate national correspondent William Saletan writes in an opinion piece. He continues, "While some extremists have been raising hell and shooting doctors, pragmatists have been hashing out common ground legislation" in the form of the Preventing Unintended Pregnancies, Reducing the Need for Abortion and Supporting Parents Act (HR 3212), which was introduced last week.Saletan writes that "a lot of bargaining" went into the legislation. He explains that abortion-rights advocates "got money for contraception and sex education," while abortion-rights opponents "got abstinence-friendly curriculum, a bigger adoption tax credit and financial support for women who continue their pregnancies." According to Saletan, each side of the abortion debate "faced the other"s truths." He provides comments from bill sponsor Rep. Rosa DeLauro (D-Conn.), who said that ""we all want to see fewer unintended pregnancies and abortions"" and that ""we must also foster an environment that encourages pregnancies to be carried to term."" According to Saletan, "Such statements are forbidden among pro-choice groups," who support "reducing the "need" for abortion, not abortion itself." He adds, "But DeLauro blurted it out. That"s what happens when you open your mind."Saletan continues that the "militant old guard of the pro-life movement" -- led by the National Right to Life Committee -- does not support the legislation, calling it a "scam." He writes that it is difficult to take seriously NRLC"s argument that the bill"s real goal is to achieve financial gains for the abortion industry. According to Saletan, the "militants extend their objection to abortion "advocacy"" because "none of the bill"s money can legally be used for abortions." By these standards, "the government can"t fund contraception programs run by anyone who thinks abortion should be legal. Which rules out nearly every contraception program in the world," Saletan writes. These opponents also condemn the bill for providing funding for ""sex education without a major abstinence component,"" despite that the bill requires grantees to ""encourage teens to delay sexual activity,"" Saletan writes. He adds, "Abstinence has become a code word for blocking any discussion of birth control."According to Saletan, "Ultimately, the militants don"t care what"s in the bill. The mere fact that some pro-choicers support it is, by their reckoning, grounds to oppose it." He continues, "Pro-life pragmatists take a different view" because they "sought, won and commend the bill"s emphasis on abstinence and parental involvement in sex education," and they "welcome its voluntary approach to abortion reduction even as they seek the procedure"s abolition." He adds, "And while some of them oppose contraception or doubt it will help, they think the bill is still worth supporting because, on balance, it will lead to fewer abortions." Saletan concludes, "I prefer the pragmatists. How about you?" (Saletan, Slate, 7/27).
The U.S. Food and Drug Administration issued a Public Health Advisory (PHA) warning consumers to stop using body building products that are represented as containing steroids or steroid-like substances. Many of these products are marketed as dietary supplements.
The nation"s struggles with physician and nurse shortages are evident as health care reform takes shape.
Cannabis Science Inc. (OTCBB: CBIS), an emerging pharmaceutical cannabis company, is pleased to report that the FDA has provided the Company with documentation to assist the Company to review and plan its initial applications to get its first drug into formal testing.
Victorian researchers have developed a wristwatch that continuously monitors the health status of people with Parkinson"s disease to help doctors manage their treatment, Victorian Minister for Innovation Gavin Jennings said today.
The GMC has launched a series of challenging online tutorials that tackle tricky ethical scenarios.
Guns smuggled from the US arm criminals in Canada and Mexico, contributing to a higher murder rate in Canada and more intense drug crime conflict near the Mexican border, according to a study published in a special issue of Criminology and Criminal Justice, published by SAGE.
Sylentis, a bio-pharmaceutical company Zeltia Group (MC: ZEL), a
The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health has stopped a clinical trial testing a drug treatment for pulmonary hypertension in adults with sickle cell disease nearly one year early due to safety concerns. In an interim review of safety data from 33 participants who completed 16 weeks of treatment, researchers found that, compared to participants on placebo (dummy pill), participants taking sildenafil (Revatio) were significantly more likely to have serious medical problems. The most common problem was episodes of severe pain called sickle cell crises, which resulted in hospitalization. No deaths have been associated with the drug in the clinical trial.
Corner shops nationwide will get help from Change4Life to sell fruit and veg - this will mean more people will get their 5 a day and shops will see an increase in profits, Secretary of State for Health Andy Burnham said today.
The International Agency for Research on Cancer (IARC) has moved sunbeds (UV tanning beds) up to the highest cancer risk category-group 1-"carcinogenic to humans". The use of sunlamps and sunbeds was until now classified as "probably carcinogenic to humans" (group 2A). IARC also moved ultraviolet radiation into group 1. These and other findings are revealed in a Special Report in the August edition of The Lancet Oncology, produced by Dr Fatiha El Ghissassi and her colleagues, IARC, Lyon, France, on behalf of the WHO International Agency for Research on Cancer Monograph Working Group.
New US legislation granting the Food and Drug Administration (FDA)
Underscoring the need for meaningful health system reform for America"s patients and physicians, the American Medical Association (AMA) is running an ad emphasizing common ground on health reform to remember what"s at stake - access to care for millions. The AMA ad runs nationally today in the Chicago Tribune, New York Times, and the Wall Street Journal. Online advertising will run in various medical trade publications.
ImmuneRegen BioSciences(R), a wholly owned subsidiary of IR BioSciences Holdings, Inc. (OTC Bulletin Board: IRBS), reports preliminary evidence that its selective Neurokinin 1-receptor agonist Homspera(R) is both active on oral administration and provides therapeutic effects against the current pandemic H1N1 virus infection.
IBM (NYSE: IBM) announced that St. Elizabeth Healthcare is connecting hospitals, clinics and physicians offices in Northern Kentucky in the state"s largest roll-out of electronic medical records to improve patient care and lower costs.
"You can think of Congress"s efforts to pay for health reform as being a little bit like a battle to slay a many-headed Hydra," writes the New York Times" economic columnist, David Leonhardt. Congress has floated idea after idea for paying for comprehensive health reform, but their proposals have failed to make ends meet because they "do not raise revenue as quickly as health costs rise." Most new taxes - such as a surtax on the rich proposed in the House - increase only as quickly as the economy, while health costs have inflated much more quickly over the last decade.
The NPA is pleased by today"s decision from the MHRA to keep pseudoephedrine a P medicine and have no doubt that community pharmacies will continue to ensure pseudoephedrine is sold in line with MHRA guidance.
The US-based PATH Malaria Vaccine Initiative (MVI), the United States Agency for International Development (USAID) Malaria Vaccine Development Program (MVDP), and Dutch biopharmaceutical company Crucell N.V. (Euronext, Nasdaq: CRXL; Swiss Exchange: CRX) today announced a collaboration to accelerate development of a promising type of malaria vaccine. Through funding from the USAID MVDP, the partners will conduct studies to determine the effectiveness of Crucell"s novel prime-boost vaccine approach against the malaria parasite, Plasmodium falciparum. This approach uses Crucell"s proprietary recombinant adenoviruses (a type of virus associated with the common cold and other mild respiratory infections) to deliver a malaria antigen to the immune system.
Elsevier announced that the Journal of Foot & Ankle Surgery (JFAS), the Official Journal of the American College of Foot and Ankle Surgeons (http://www.acfas.org), has been accepted for coverage by multiple Thomson Reuters abstracting and indexing services, including Journal Citation Reports®.
Although Hispanic women tend to develop breast cancer less than Caucasian women, it is usually more aggressive and advanced when it does develop.
To learn from experience, it is essential to know whether a past action was associated with a desired outcome. Now, scientists have demonstrated how this information can be coded by a single cell. The research, published in the July 30th issue of the journal Neuron, provides strong support for a neural mechanism that allows reward signals to be combined over time to drive successful learning.
A systematic literature review of mothers" experiences with bottle-feeding found that while mothers recognize the benefits of breastfeeding, those who bottle-feed with infant formula do not receive adequate information and support from their healthcare providers and thus, ultimately put their baby"s health at risk. "While it is important to promote breastfeeding," the authors conclude, "it is also necessary to ensure that the needs of bottle-feeding mothers are not overlooked."
Around one in five young people in the U.S. have a current mental, emotional, or behavioral disorder. About half of all adults with mental disorders recalled that their disorders began by their mid-teens and three-quarters by their mid-20s. Early onset of mental health problems have been associated with poor outcomes such as failure to complete high school, increased risk for psychiatric and substance problems, and teen pregnancy.
A research team comprised of faculty at Worcester Polytechnic Institute"s (WPI) Life Sciences and Bioengineering Center (LSBC) and investigators at CellThera, a private company also located at the LSBC, has discovered a novel way to turn on stem cell genes in human fibroblasts (skin cells) without the risks associated with inserting extra genes or using viruses. This discovery opens a new avenue for reprogramming cells that could eventually lead to treatments for a range of human diseases and traumatic injuries by coaxing a patient"s own cells to repair and regenerate the damaged tissues.
Informa Healthcare - one of the world"s leading medical and scientific publishers- has announced that the new interactive http://www.informahealthcare.com site is now live and delivers online content from more than 180 peer-reviewed journals.
[Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men
Older adults who have less strength, poor physical function and low muscle density are at higher risk of being hospitalized compared to adults with more strength and better function. That"s the finding of a new study in the Journal of the American Geriatric Society.
Sciele Pharma Inc., a Shionogi Company, and Plethora Solutions Holdings PLC ("Plethora" - AIM:PLE), announced that a second and final Phase III double-blind, placebo-controlled study of PSD502 for the treatment of premature ejaculation ("PE") has met all co-primary endpoints of Intra-vaginal Ejaculation Latency Time ("IELT"), Index of Premature Ejaculation ("IPE," Ejaculatory Control, Sexual Satisfaction and Distress domains).
U.S. Senators Mel Martinez (R-FL) and Evan Bayh (D-IN) introduced a measure to create a collaborated system for researching, treating and eliminating Alzheimer"s disease. The proposal will create an Office of the National Alzheimer"s Project within the White House, and will coordinate all research, clinical care and service toward the prevention, care, and cure of Alzheimer"s. This office will produce a national strategic plan to help assure that the millions of Americans who now have Alzheimer"s and the millions of potentially at-risk Americans will have a coordinated effort to target the 6th leading cause of death in the United States.
Foot complications, such as open wounds and ulcers, can be one of the most difficult ailments for a podiatrist to treat. However, a new wound dressing powder, which acts very much like a layer of skin, is proving to speed the healing time and reduce the amount of pain that a patient suffering from a serious foot ulcer would normally experience. This includes open sores on the feet as a result of inflammatory bowel disease, diabetes or skin cancer. The study results will be released at the American Podiatric Medical Association"s (APMA) 97th Annual Scientific Meeting in Toronto, July 30 - August 2, 2009, and will highlight the powder"s unique ability to rapidly heal foot wounds and advance the treatment patients currently receive.
United Therapeutics Corporation (Nasdaq: UTHR) announced that the United States Food and Drug Administration (FDA) has approved TYVASO (treprostinil) Inhalation Solution for the treatment of pulmonary arterial hypertension (PAH) using the TYVASO Inhalation System (which includes the Optineb-ir device and accessories). TYVASO is indicated to increase walk distance in patients with NYHA Class III symptoms associated with WHO Group I PAH, which includes multiple etiologies such as idiopathic and familial PAH as well as PAH associated with scleroderma and congenital heart disease.
The Department of Health announced that the terms offered to independent providers of treatment centres in the NHS in England will in future be more similar to those offered to NHS providers.
With the implementation of the 48-hour working week for workers throughout Europe, including doctors, on 1 August 2009, the BMA in Northern Ireland has said that it will insist that the health service must meet its obligations to implement the European Working Time Directive (EWTD).
The future use of Independent Sector Treatment Centres (ISTCs) in the NHS, will be fairer and on the same terms as other providers of NHS services, Health Minister Mike O"Brien announced today.
A new education programme has been developed to provide enhanced training in genetic technologies and clinical applications for healthcare scientists working in laboratory genetics, Health Minister Ann Keen announced.
The body"s nanomachines that read our genes don"t run as smoothly as previously thought, according to a new study by University of California, Berkeley, scientists.
To fulfill America"s humanitarian obligations as a member of the international community and to invest in the nation"s long-term health, economic interests, and national security, the United States should reaffirm and increase its commitment to improving the health of developing nations, says a new report from the Institute of Medicine.
House Democrats on Wednesday made a deal with fiscally conservative Blue Dog Democrats on a health reform bill that "would reduce the overall cost of the package and ensure more funding for rural hospitals, concessions that could allow the Energy and Commerce Committee to finish its consideration of the legislation," The Washington Post reports. The deal will be considered on the House floor no earlier than September, according to several lawmakers. House lawmakers plan to conclude their markup of the legislation in the Energy Committee Thursday.
This is the time of year when even teens who have never tried a drop of alcohol may be tempted. Middle and high school proms and graduation are big events and there will be multiple parties to attend and a wide array of opportunities for alcohol to be served.
The Associated Press reports: "Federal authorities arrested more than 30 suspects, including doctors, and were seeking others in a major Medicare fraud bust Wednesday in New York, Louisiana, Boston and Houston, targeting scams such as "arthritis kits" - expensive braces that many patients never used. More than 200 agents worked on the $16 million bust that included 12 search warrants at health care businesses and homes across the Houston area, where the bulk of the arrests were made. Federal authorities say those businesses were giving patients "arthritis kits," which were nothing more than expensive orthotics that included knee and shoulder braces and heating pads. Patients told authorities they were unnecessary and many never even received them. But health care clinic owners billed between $3,000 to $4,000 for each kit. ... In some cases, clinic owners billed patients who were dead when they allegedly received the items" (Kennedy, 7/29).
This week long observation of the importance of breastfeeding is organized by the World Breastfeeding Week organization (worldbreastfeedingweek.org). The theme this year is the importance of breastfeeding during emergency situations. It is important that when natural or man-made disasters strike that all involved remember the importance of maintaining and supporting breastfeeding of infants affected by the disaster.
"Expanded testing across India in the past three years shows a 2,000 percent jump in the number of HIV cases among children, [Ghulam Nabi Azad] the country"s health minister announced Wednesday," CNN reports. As of May 2009, reports found that nearly 53,000 children are living with HIV in India - up from 2,253 recorded cases in November 2006, Azad said during an address to the parliament (Singh, 7/29).
Prescribers treating patients who have had total hip or knee replacement surgery can access an independent review of the oral anticoagulant rivaroxaban (Xarelto) in the August issue of NPS RADAR.
There is growing concern among California HIV/AIDS advocates "that the Golden State will reverse course and see spikes in new HIV cases after Republican Governor Arnold Schwarzenegger this week further slashed the state Office of AIDS budget in order to deal" with a more than $20 billion deficit, the Bay Area Reporter reports (Bajko, 7/30). David Brinkman, executive director of the Desert AIDS Project in Palm Springs, which provides services to people living with HIV in the area, said, "This is the worst-case scenario cut. It"s going to cut, possibly eliminate [HIV] education" (Brambilla, Desert Sun, 7/29).
Short-term complications and death rates were low following bariatric surgery to limit the amount of food that can enter the stomach, decrease absorption of food or both, according to the Longitudinal Assessment of Bariatric Surgery (LABS-1). The study was funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. Results are reported in the July 30 issue of the New England Journal of Medicine.
The incidence of a rare and deadly tumor called primary central nervous system lymphoma (PCNSL) is two times higher in black Americans, ages 20 to 49, than in white Americans, according to a Mayo Clinic study published in the June issue of Journal of Neuro-Oncology. In patients older than 49, the results were reversed. White Americans were twice as likely as black Americans to be diagnosed with PCNSL.
A study led by scientists in Austria suggests that kids as young as 9 years old can and should learn how to use CPR (cardiopulmonary
The biotechnology medicine Ilaris® (canakinumab) has passed another major milestone with a recommendation for approval in the European Union to treat patients with a life-long and potentially fatal auto-inflammatory disease called cryopyrin-associated periodic syndrome (CAPS). When approved, Ilaris will be the only treatment in the EU indicated for CAPS patients aged four years and older[1].
Parkinson"s disease is well-known for impairing movement and causing tremors, but many patients also develop other serious problems, including sleep disturbances and significant losses in cognitive function known as dementia.
"While Americans may complain about the high cost of health care, they"re still willing to shell out roughly $34 billion a year out-of-pocket on alternative therapies that aren"t covered by insurance, a new study shows," USA Today reports. Spending on the complementary and alternative therapies has increased by 25 percent in the last decade, according to the study by the Centers for Disease Control and Prevention and the National Institutes of Health (Szabo, 7/30).
"The U.N. unveiled a multimillion dollar strategy a dozen years ago to save children worldwide, but a new [Lancet] study has found the program had surprisingly little effect in Bangladesh, one of the world"s poorest countries," the Associated Press reports. Since 1997, when the WHO and UNICEF launched the Integrated Management of Childhood Illness (IMCI) Program to help reduce the numbers of deaths in children under age 5 from diarrhea, pneumonia, measles and malnutrition, more than 100 countries have adopted the program, drawing upon "millions" in aid, according to the news service.
"A U.S. plan to rely on swine flu vaccines without ingredients to stretch the supply [known as adjuvants] would reduce the number of available shots just when other countries need them most, the British journal Lancet said in an editorial," Bloomberg writes. On July 7, the WHO recommended the use of adjuvants - "mixes of oil and water that trigger a stronger response in the body to antigen, the substance that induces immunity" - to increase the global vaccine supply. Though adjuvants are not approved for flu vaccines in the U.S., HHS" decision to declare the H1N1 flu a public health emergency in April gave the FDA the go-ahead to use "unapproved medical products including adjuvants," according to Bloomberg.
China Aoxing Pharmaceutical Company, Inc. (OTCBB: CAXG) ("China Aoxing"), a pharmaceutical company specializing in research, development, manufacturing and marketing of narcotic and pain-management products, announced that it has acquired all rights to TJSL, a novel drug at Phase II development stage to treat primary dysmenorrhea ("PD"), or menstrual pain, in adult women.
According to the latest data in a clinical study supported by St. Jude Medical, Inc. (NYSE:STJ), deep brain stimulation (DBS) therapy for depression may provide sustainable improvement in depression symptoms among patients with major depressive disorder. Study results will be presented at the American Psychiatric Association (APA) meeting in San Francisco.
Global Health Aid Should Take An "Integrated Approach"
Patients with second primary lung cancers (SPLC), when compared to those with one primary lung cancer (OPLC), are more likely to have localized disease at the time of diagnosis and are more likely to receive surgical treatment rather than radiation treatment. However, patients with SPLC have a 12% higher lung cancer specific mortality, Fox Chase Cancer Center researchers reported at the annual meeting of the International Association for the Study of Lung Cancer.
Transposons are mobile genetic elements found in the hereditary material of humans and other organisms. They can replicate and the new copies can insert at novel sites in the genome. Because this threatens the whole organism, molecular mechanisms have evolved which can repress transposon activity. Professor Klaus Förstemann of the Gene Center of Ludwig-Maximilians-Universität (LMU) in Munich and a team of researchers working with the fruitfly Drosophila melanogaster have now uncovered a new type of cellular defence that acts against DNA sequences present in high copy numbers inside the cell, even if they have not integrated into the genome. Small molecules of RNA (a class of nucleic acid closely related to the genetic material DNA) play the central role. "Transposons are genomic parasites, so to speak", says Förstemann. "If they are allowed to proliferate, the genome can become unstable or cancers can develop. We now want to find out whether mammalian cells possess this newly discovered defence mechanism and to elucidate precisely how it works." (EMBO Journal online, 30 July 2009.)
UroToday.com - Ureaplasma urealyticum and Mycoplasma Hominis are members of a unique group of microorganisms commonly identified in the genital tract of women. With the onset of sexual intercourse the prevalence of Mycoplasma increases dramatically an isolation is strongly dependent on the number of sexual partners. Convincing evidence of an infection caused by genital Mycoplasma is not easy, because they usually are not isolated in pure culture, making the evaluation even more difficult.
UroToday.com - Patients with pain can present with various symptom complexes that include interstitial cystitis, vulvodynia, irritable bowel syndrome, myofascial pain or various causes of dyspareunia but when carefully evaluated, the majority have very similar findings. No matter what their primary complaint might be over 70% of patients will have hypertonic pelvic floor dysfunction and/or pain as well as a component of at least one visceral pain syndrome such as interstitial cystitis (the most common), chronic pelvic pain or irritable bowel syndrome.
UroToday.com - Most recently, health-related quality-of-life (HRQOL) after definitive local therapy for prostate cancer has been argued in the patient group with an oncological risk category. [1] Prior to such controversy, we thought that posttreatment HRQOL issues or functional outcomes possibly vary among oncological risk categories, and compared both oncological and functional outcomes between patients receiving radical prostatectomy (RP) and those undergoing external beam radiation therapy (EBRT) with risk stratification. [2] Indeed, we found that the low- and intermediate-risk patients in the RP group reported poorer urinary function than those in the EBRT group.
Participants in the University of Wisconsin-Madison"s
Congressman Michael C. Burgess, M.D. (R-Texas), a member of the House Energy and Commerce Committee, released the following statement after the Committee favorably reported HR 3200, the Democrat health care reform bill, by a vote of 31 to 28
The Turner Syndrome Society of the United States (TSSUS) recently concluded its 22nd Annual Conference in Portland, Oregon. The conference drew more than 350 individuals, families, researchers and health care professionals to network and learn about the latest research breakthroughs benefiting women and girls with TS.
AVEO Pharmaceuticals, Inc., a biopharmaceutical company leveraging breakthrough discoveries in cancer biology to discover, develop and commercialize targeted oncology therapies, today announced data which demonstrates that tivozanib (AV-951) - the company"s oral, triple VEGF receptor inhibitor - exhibits potent anti-angiogenic and anti-tumor activity in AVEO"s proprietary in vivo lung cancer models. Specifically, treatment with tivozanib resulted in complete tumor growth inhibition or tumor regression (shrinkage) in lung tumors driven by EGFR or KRAS mutations, which are especially difficult to treat. These data are being presented today at the 13th World Conference on Lung Cancer (WCLC) in San Francisco, abstract number PD10.1.5.
A marked and broad expansion in antidepressant treatment occurred among Americans older than 6 years between 1996 and 2005, although treatment rates remain low among racial and ethnic minorities, according to a report in the August issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
Taking opioid drugs without a prescription appears relatively common among high school seniors, according to a report in the August issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals. The most common reasons survey respondents gave for taking the medications included relaxation, feeling good or getting high, experimentation and pain relief.
Physicians should recommend low to moderate levels of exercise to their pregnant patients, even if they have not exercised prior to pregnancy, states a report published in the August 2009 issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS). According to this review article, exercise can strengthen and improve overall musculoskeletal and physiologic health as well as pregnancy related symptoms. Exercise such as aerobics, impact and nonimpact activities, resistance training and swimming:
As people age, the potential exists for those years to be the most rewarding and fulfilling time of their lives. However, major illness, retirement, the death of a spouse, and a shrinking circle of friends all may, in some cases, contribute to increased levels of stress and depression in the elderly. For that reason the chief of geropsychiatry for the Los Angeles Jewish Home - the largest single- provider of senior residential housing in the western United States - is offering seniors and their loved ones 10 warning signs that may trigger the need for assistance with mental health issues.
In the final week of debate before the Senate recess, the Finance Committee continues talks on bipartisan legislation, but both Republicans and Democrats are ramping up their health care rhetoric and considering more drastic options.
A former Clinton administration official said last week that there aren"t enough doctors in America to handle the increase in patients if health reform covers more uninsured, NPR reports.
California"s experience with insurance exchanges could prove a valuable lesson for the nation"s flirtation with such pools for covering large numbers of people, The Wall Street Journal reports.
A new deal to balance California"s budget may have serious repercussions for the health of the state"s children, while South Carolina grapples with health cuts of its own. Meanwhile, New Jersey may become one of the first states to publically disclose hospital errors.
A Wilmington News Journal editorial discussed the potential lifting of the ban on using federal funding for needle exchange programs. The editorial notes recent Congressional action and the restrictions in a House bill that prohibit needle exchanges to operate "within a 1,000 feet of day care centers, schools, parks, playgrounds, pools and youth centers." According to the News Journal, "This rule wipes out much of the flexibility many cities need in their fight to prevent the spread of HIV among intravenous drug users. The nation"s capital, where the rates of HIV and AIDS cases are considered epidemic, would be hit the hardest because no part of the District of Columbia would be eligible for the funding according to AIDS Action." The editorial adds, "Vans patrolling near vulnerable populations - specifically young, impressionable children - are an issue that must be addressed. But well-intentioned limits should not be allowed to hold up the rest of the program," according to the News Journal (8/1).
Study 1 Twins born as a result of assisted reproductive technology (ART) are more likely to be admitted to neonatal intensive care and to be hospitalised in their first three years of life than spontaneously conceived twins, according to new research published online in Human Reproduction [1].
The House Energy and Commerce Committee on July 31 approved its health care reform bill (HR 3200) by a 31-28 vote that was mostly along party lines, the AP/Seattle Times reports. Among the many amendments considered during the markup, the committee rejected an amendment offered by Reps. Joe Pitts (R-Pa) and Bart Stupak (D-MI) to prohibit government subsidies to any insurance plans that offers abortion coverage, effectively prohibiting abortion coverage for customers eligible for public premium assistance. The amendment was rejected by a 27-31 vote. Another provision approved on July 30 would neither require nor prohibit insurance companies from providing coverage for abortion services.The approved bill includes provisions limiting how much insurers can increase premiums and gives the federal government the power to negotiate with drug companies for lower prices under Medicaid. The provisions were part of an effort by Democrats on the committee to reconcile the demands of liberals and conservatives, the AP/Times reports. The bill also would require insurance companies to sell coverage to anyone seeking it, regardless of pre-existing conditions. The government would provide subsidies to lower-income families to help them afford policies. In addition, the legislation would establish health insurance exchanges offering a variety of insurance plans, where consumers with or without subsidies could purchase health insurance (Espo/Werner, AP/Seattle Times, 8/1).Five of the committee"s Democrats joined all 23 Republicans in opposing the measure, the Washington Post"s "Capitol Briefing" reports. The five Democrats who voted against the bill were Reps. John Barrow (Ga.), Rick Boucher (Va.), Jim Matheson (Utah), Charlie Melancon (La.) and Bart Stupak (Mich.) (Kane, "Capitol Briefing," Washington Post, 7/31).The committee was the last of three House panels to take action on the legislation, although the vote comes several weeks after the White House and Democratic leaders originally wanted, the AP/Times reports. The full House is expected to vote on the bill after policymakers return from their August recess.Although the House"s agenda has moved slower than party leaders had hoped, it still was faster than the action in the Senate, according to the AP/Times (AP/Seattle Times, 8/1). Senate Finance Committee Chair Max Baucus (D-Mont.) on July 30 announced that the panel will not mark up a health care reform bill this week after Republican negotiators urged that the speed of discussion in the Senate be slowed, the Post"s "44" reports. The announcement means that health care reform legislation will not be out of committee in both chambers before the summer recess (Pershing, "44," Washington Post, 7/31).Catholic Bishops Say That House Bill Could Expand Abortion Coverage In related news, the U.S. Conference of Catholic Bishops in a letter to members of the House Energy and Commerce Committee voiced its opposition to the reform bill, arguing that it could be used to require private health insurance plans to cover abortion services, the Post reports. The bill has been opposed by conservative Christian groups for weeks, with the groups arguing that it could be used to expand abortion rights, the Post reports.In the letter, Cardinal Justin Rigali -- chair of the Committee on Pro-Life Activities -- said the bill could increase federal funding for abortion services because some government funding would not be covered by the Hyde Amendment, which currently bans the use of federal Medicaid funds for abortion services. Rigali also said the bill could overturn state laws that restrict access to abortion services, such as parental notification laws. In addition, Rigali said the bill should continue to ensure provider conscience rights to protect Catholic health care workers who refuse to provide abortion services based on their religious or moral beliefs (Washington Post, 8/1).
Francis Collins, President Obama"s pick to head NIH, and Regina Benjamin, Obama"s surgeon general nominee, have spoken publicly about their religious beliefs but also have expressed views on issues such as embryonic stem cell research that conflict with church teachings, USA Today reports. Collins, who headed the Human Genome Project, is an evangelical Christian who supports the use of human embryonic stem cells in some medical research. Focus on the Family in a newsletter lauded Obama"s choice of an evangelical to lead NIH but said that abortion-rights opponents cannot support Collins" views, "particularly since he supports destructive human embryonic stem cell research."Benjamin is a Roman Catholic and sits on the board of the Catholic Health Association. She also is active in her local church and received a papal medal in 2006. According to USA Today, Catholic leaders from her native state of Alabama say they have not heard Benjamin voice support for abortion rights. The Bayou La Batre, La., medical clinic that she oversees does not perform abortions. Bill Donohue, president of the Catholic League, initially expressed support for Benjamin"s nomination, saying, "Her tireless and selfless efforts are a model for all physicians." He later said that he opposes any possible support she might give "mandated abortion coverage" in health reform.The White House has said that Benjamin agrees with Obama "on reproductive issues." Retired archbishop Oscar Lipscomb, who nominated Benjamin for the papal medal, said, "She is a practicing Catholic and faithful and, to the best of my knowledge, in all those questions that have arisen so far, there has never been a conflict in her practice and in her conversation with regard to what the church expects of medical practitioners." Former Surgeon General David Satcher, who taught Benjamin at Morehouse School of Medicine, said, "While the religion of the surgeon general may very well influence his or her ... approach, the message has to be the public health science," adding, "It"s not a religious message. It"s a public health science message."Emilie Townes, associate dean of academic affairs for Yale Divinity School, said that Obama"s choices represent his aim to "break the mold" of traditional politics, adding that Collins and Benjamin are examples of "big tent" evangelicalism and Catholicism (Banks, USA Today, 8/3).
Rummaging through a biotechnology company"s chemical closet, Yale University researchers found two molecules that will allow scientists to better study how cells move. The study in the journal Nature, published online Aug. 2, describes how two small molecules discovered by Cytokinetics Inc. block the action of a key complex that directs the assembly of actin filaments, which produce the force to help cells move. The target of these inhibitors is the Arp2/3 complex, a cellular component so vital that cells die without it. This dependence has made it challenging to learn exactly which cellular processes depend upon the complex.
Daytime temperature fluctuations greatly alter the incubation period of malaria parasites in mosquitoes and alter transmission rates of the disease. Consideration of these fluctuations reveals a more accurate picture of climate change"s impact on malaria.
Pregnant women with mild hypertensive disorders such as high blood pressure/mild pre-eclampsia^ should have their labour induced once they complete 37 weeks of their pregnancy. This is the conclusion of the HYPITAT study, published in an Article Online First and in an upcoming edition of The Lancet, written by Dr Corine M Koopmans, Department of Obstetrics and Gynaecology, University Medical Centre Groningen, Netherlands, and colleagues.
The Australian Medical Students" Association acknowledges the Australian Medical Association"s call for action concerning the difficulties that doctors face in maintaining involvement in teaching and research activities.
Speaker Nancy Pelosi issued the following statement tonight on the vote by the House Energy and Commerce Committee to pass the America"s Affordable Health Choices Act, the third House committee to pass the bill this month. The House Ways and Means Committee and Education and Labor Committee approved the bill earlier this month:
The recent H1N1 pandemic has highlighted the importance of identifying public health measures which can help to mitigate flu virus transmission. Researchers conducted a prospective cluster-randomized trial to test whether improved hand hygiene or surgical face masks could reduce the spread of flu within households.
The new medical consensus statement on accelerated partial breast irradiation is an important step toward defining patient selection criteria and highlights the importance of targeting radiation, said two of the nation"s leading APBI physicians.
Congressman Michael C. Burgess, M.D. (R-Texas) sent a letter to President Obama yesterday accepting his invitation to "come over to the White House and go over line-by-line" the health care reform plan the President is pushing.
Cephalon, Inc. (Nasdaq: CEPH) announced yesterday that the Journal of Clinical Oncology has published data from a pivotal phase 3 study demonstrating that TREANDA® (bendamustine HCl) for Injection improved clinical outcomes when compared to chlorambucil in patients with chronic lymphocytic leukemia (CLL). Results of this study were the basis of the March 2008 U.S. Food and Drug Administration (FDA) approval of TREANDA for CLL, the first agent approved by the FDA for this disease since 2001. According to the American Cancer Society, there will be more than 15,000 new cases of CLL diagnosed in 2009 alone. The study results were published online today and will also appear in the print edition later this year.
As the field of stem cell based therapies has progressed, there have been numerous questions about the exact way one of the most promising lines of adult stem cells works to repair damaged heart muscle. Although cells obtained from adult bone marrow are proving to be useful to treat heart disease, there has been a major controversy over whether they are true stem cells capable of forming new heart muscle.
In a major step in spinal cord injury research, scientists at the University of California, San Diego School of Medicine have demonstrated that regenerating axons can be guided to their correct targets and re-form connections after spinal cord injury. Their findings were published in the advance online edition of the journal Nature Neuroscience on August 2.
Heart specialists at St. Joseph Hospital in Orange, Calif. have performed a new procedure in which they repaired a hole in the patient"s heart through a tiny incision, offering the patient a much safer alternative verses open heart surgery.
PEAK Surgical, Inc. announced the launch of the PEAK((R)) PlasmaBlade TnA (Tonsil and Adenoid) tissue dissection device following 510(k) clearance from the U.S. Food and Drug Administration (FDA). This new product is indicated for cutting and coagulation of soft tissue during otolaryngology (ear, nose and throat [ENT]) surgery, including removal of the tonsils and adenoids.
Divers who held their breath for several minutes had elevated levels of a protein that can signal brain damage, according to a new study from the Journal of Applied Physiology. However, the appearance of the protein, S100B, was transient and leaves open the question of whether lengthy apnea (breath-holding) can damage the brain over the long term.
An article published Online First exposes the facts of the poisoning of Ukrainian President Victor Yushchenko in 2004. It is the work of Professor Jean Saurat, from the Swiss Centre for Human Applied Toxicology, and the University Hospital, in Geneva, Switzerland, and his collaborators. It establishes that there is a need for routine analytical techniques to test for metabolites of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) which is a type of dioxin and the poison that was used. This will help to provide proper treatment.
Today, the Maricopa County Department of Public Health in cooperation with Phoenix Elementary School District has closed Lowell Elementary School until May 26, 2009 due to a high rate of influenza like illness.
PAHO on Monday announced it had found Tamiflu-resistant H1N1 (swine) flu along the Texas-Mexico border, Agence-France Press reports. The discovery of several cases in El Paso and McAllen, Texas, adds the U.S. to a growing list of countries with antiviral-resistant H1N1, such as Canada, Denmark, Hong Kong and Japan. "Experts had gathered in La Jolla on Monday to discuss the response to the outbreak, and warned that resistant strains were likely emerging because of overuse of antivirals like Tamiflu," the news service writes (8/3).
Officials at an East Texas health care organization, Health Horizons, which provides HIV testing and other services to people in 12 counties, "has seen more East Texans test positive for [HIV] so far this year than it did for all of 2008," the Lufkin Daily News reports. Executive Director Wilbert Brown said, "We"ve had eight people out of more than 800 test positive for HIV in the first seven months of this year. Most of those have been African-American men. Last year we had a total of six out of more than 1,000. I expect us to see two or three more positives before the year is out. The state average for testing positive is one in 100, and we"re getting close to that number." According to the article, "Brown said he attributes the increase to Health Horizon"s aggressive outreach program targeting high-risk groups and to people realizing the importance of getting tested." The Daily News article also profiles a client of Health Horizons (Cooley, 8/2)
Large number of individuals, such as recovery and rescue workers, nearby residents and office workers, who experienced intense or prolonged exposure to the World Trade Center attack have reported new diagnoses of asthma or posttraumatic stress 5-6 years after the attack, according to a study in the August 5 issue of JAMA, a theme issue on violence and human rights.
On average, not-for-profit nursing homes deliver higher quality care than do for-profit nursing homes, according to a study published on bmj.com today.
In its fight against an intruding virus, an enzyme in our immune system may sense certain types of viral RNA pairs, according to scientists.
GP Surgeries in Camden are successfully sending out text messages advising patients on what to do if they think they have Swine Flu.
Due to workforce shortages, doctors are struggling to maintain their involvement in teaching and in research activities, according to an article published in the Medical Journal of Australia. Further, the demands for doctors to teach medical students and doctors-in-training are increasing, with even more medical students now enrolled.
NeurogesX, Inc. (Nasdaq: NGSX), a biopharmaceutical company focused on developing and commercializing novel pain management therapies, announced that the United States Food and Drug Administration (FDA) has extended the Prescription Drug User Fee Act (PDUFA) date from August 16, 2009 to November 16, 2009 to review the new drug application (NDA) for Qutenza(TM) to manage pain associated with postherpetic neuralgia (PHN).
In the first study of its kind, researchers at Saint Louis University are recruiting patients for a clinical trial that will use cutting-edge imaging equipment to map the brain injuries of combat veterans and civilians, aiming to better understand the nature of their injuries. Funded by a $5.3 million grant from the U.S. Department of Defense, researchers will use three types of imaging equipment together, producing better data and a more complete taxonomy of brain injuries, information that investigators hope may lead to better treatment for blast injuries and car accidents.
The structure of an entire HIV genome has been decoded for the first time by researchers at the University of North Carolina at Chapel Hill. The results have widespread implications for understanding the strategies that viruses, like the one that causes AIDS, use to infect humans.
UroToday.com - Microdissection testicular sperm extraction is a procedure used to extract sperm from patients with irreversible non-obstructive azospermia. Sperm extracted are then used for in vitro fertilization (IVF). While this technique has improved the sperm retrieval rate compared to other biopsy techniques, sperm are still often not retrieved. The purpose of our research was to develop a technique for identifying small foci of sperm for retrieval for use in IVF.
The following summarizes recent articles on breast and ovarian cancer research.~ Breast cancer: For the first time, a large international breast cancer study to determine the effectiveness of radiation therapy after mastectomy will include 200 Chinese women, the New York Times reports. Asian women traditionally have had relatively low breast cancer rates. However, that trend is reversing in China, where breast cancer is on the rise because of rapid urbanization, pollution and diet changes. In addition, China"s one-child policy could be contributing to the trend, as breast cancer is less common in women with more children. Chief researcher Ian Kunkler, a professor at the Edinburgh Cancer Research Center, said that although pharmaceutical companies have done clinical trials of chemotherapy drugs in China, "no patient in China has ever been recruited into a randomized controlled trial for breast radiotherapy." Kunkler"s trial will include about 3,700 participants overall from Australia, Britain and other parts of Europe, Japan and Singapore (Caryn Rabin, New York Times, 8/3).~ Ovarian cancer: Two recently published studies have provided new insight into the early stages of ovarian cancer, potentially increasing the likelihood of developing better diagnostic tests, the Wall Street Journal reports. A study published in the journal Nature Genetics has identified a common gene variation called BNC2. Scientists predict that when BNC2 is combined with other gene variations, the result dramatically increases the risk of ovarian cancer. Researchers involved in a study published in the online journal PLoS have determined that ovarian tumors of the BRCA1 mutation exist in the body for about four years before metastasizing but remain less than one centimeter in diameter during that time. They also found that only about half of the tumors grow to be three centimeters in diameter when they do spread (Beck, Wall Street Journal, 8/4).
Americans appear split over the president"s push for health care reform, a new CNN poll has found. "Fifty percent of those questioned in CNN/Opinion Research Corporation survey released Wednesday morning say they support the president"s plans, with 45 percent opposed. The results indicate a generational divide. ""Obama"s plan is most popular among younger Americans and least popular among senior citizens," says CNN Polling Director Keating Holland. "A majority of Americans over the age of 50 oppose Obama"s plan; a majority of those under 50 support it.""
Results of a new study confirm trends that different Hispanic population groups have higher incidence rates of certain cancers and worse cancer outcomes if they live in the United States, than they do if they live in their homelands.
The Advisory Committee on Immunization Practices recommends the human papillomavirus vaccination for all 11- and 12-year-old girls, but results of a recent survey showed that more than half of Texas physicians do not follow these recommendations.
Malaria Cases, Deaths In Cambodia Increase
In a presentation at the current General Meeting of the American Society for Microbiology (ASM) being held in Philadelphia, PA, a simple and inexpensive developmental diagnostic assay produced by MicroPhage, Inc., http://www.microphage.com, was shown to be highly accurate for rapid identification of serious staph bacterial infections from skin and soft tissue infections.
Altair Therapeutics, Inc., a privately-held, biopharmaceutical company developing novel therapeutics for respiratory diseases, reported results from its phase I study evaluating the safety, tolerability and pharmacokinetics of its lead product, once-weekly inhaled AIR645, in healthy volunteers. AIR645 is a non-steroidal dual inhibitor of cellular responses to interleukin (IL)-4 and IL-13, cytokines that play a critical role in development and progression of asthma, rhinitis and other allergic disorders. Results presented today at the 2009 International Conference of the American Thoracic Society (ATS) within the Mini-Symposium "New Treatment Approaches for Asthma and Allergy" showed that inhaled AIR645 was safe, well tolerated and had dose-dependent exposure in the airways. These results demonstrate the potential of AIR645 as a convenient once-weekly treatment for asthma and other respiratory disorders. Later this year, Altair plans to initiate a phase II efficacy study in patients with asthma.